MGP Database

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MGP005975

UniProt Annotations

Entry Information
Gene Namechromodomain helicase DNA binding protein 9
Protein EntryCHD9_HUMAN
UniProt IDQ3L8U1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q3L8U1-1; Sequence=Displayed; Name=2; IsoId=Q3L8U1-2; Sequence=VSP_018086; Name=3; IsoId=Q3L8U1-3; Sequence=VSP_018085, VSP_018086;
Catalytic ActivityATP + H(2)O = ADP + phosphate.
FunctionActs as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity). {ECO:0000250}.
InteractionQ07869:PPARA; NbExp=2; IntAct=EBI-960730, EBI-78615;
PtmPhosphorylated on serine and tyrosine residues. {ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:17081983, ECO:0000269|PubMed:18669648, ECO:0000269|PubMed:19690332, ECO:0000269|PubMed:20068231}.
Sequence CautionSequence=AAF24170.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAB14112.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
SimilarityContains 1 helicase ATP-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00541}.
SimilarityContains 1 helicase C-terminal domain. {ECO:0000255|PROSITE-ProRule:PRU00542}.
SimilarityContains 2 chromo domains. {ECO:0000255|PROSITE- ProRule:PRU00053}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16095617}. Nucleus {ECO:0000269|PubMed:16095617}.
SubunitInteracts with PPARA. Probably interacts with ESR1 and NR1I3. {ECO:0000269|PubMed:16554032}.
Tissue SpecificityWidely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts. {ECO:0000269|PubMed:16095617, ECO:0000269|PubMed:16554032}.
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