MGP Database

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MGP005981

UniProt Annotations

Entry Information
Gene NameER degradation enhancer, mannosidase alpha-like 3
Protein EntryEDEM3_HUMAN
UniProt IDQ9BZQ6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BZQ6-1; Sequence=Displayed; Name=2; IsoId=Q9BZQ6-2; Sequence=VSP_056375, VSP_056376; Note=No experimental confirmation available.;
Catalytic ActivityHydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2).
DomainContains a protease-associated domain (PA) of unknown function.
FunctionInvolved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:25092655}.
Sequence CautionSequence=AAG60613.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37573.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyl hydrolase 47 family. {ECO:0000305}.
SimilarityContains 1 PA (protease associated) domain. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
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