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MGP005986

Record overview

MGPD IDMGP005986
Gene ID80310
SpeciesHomo sapiens (Human)
Gene Nameplatelet derived growth factor D
Gene Symbol PDGFD
SynonymsIEGF; SCDGFB; MSTP036; SCDGF-B;
Alternate namesplatelet-derived growth factor D; PDGF-D; iris-expressed growth factor; spinal cord derived growth factor B; spinal cord-derived growth factor B; spinal cord-derived growth factor-B;
Chromosome11
Map Location11q22.3
SummaryThe protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PDGFD

Proteins

platelet-derived growth factor D isoform 1 precursor
Refseq ID:NP_079484
Protein GI:13376808
UniProt ID:Q9GZP0
mRNA ID:NM_025208
Length:370
RefSeq Status:
MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFG
LEEAENDICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSV
TDPTLIADALDKKIAEFDTVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQ
RCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR
 
sig_peptide: 1..23
calculated_mol_wt: 2665
peptide sequence: 
MHRLIFVYTLICANFCSCRDTSA

mat_peptide: 24..370
product: platelet-derived growth factor D isoform 1
calculated_mol_wt: 40201
peptide sequence: 
TPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDISETS
TIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDL
LKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKT
VKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR
 
platelet-derived growth factor D isoform 2 precursor
Refseq ID:NP_149126
Protein GI:15451921
UniProt ID:Q9GZP0
mRNA ID:NM_033135
Length:364
RefSeq Status:
MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAEN
DICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLI
ADALDKKIAEFDTVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNC
GCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR
 
sig_peptide: 1..23
calculated_mol_wt: 2665
peptide sequence: 
MHRLIFVYTLICANFCSCRDTSA

mat_peptide: 24..370
product: platelet-derived growth factor D isoform 1
calculated_mol_wt: 40201
peptide sequence: 
TPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDISETS
TIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDL
LKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKT
VKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR

sig_peptide: 1..13
calculated_mol_wt: 1580
peptide sequence: 
MHRLIFVYTLICA

mat_peptide: 14..364
product: platelet-derived growth factor D isoform 2
calculated_mol_wt: 40605
peptide sequence: 
NFCSCRDTSATPQSASIKALRNANLRRDDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDI
SETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDT
VEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCN
SGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR
 
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