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MGP006010

Record overview

MGPD IDMGP006010
Gene ID80896
SpeciesHomo sapiens (Human)
Gene NameN-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
Gene Symbol NPL
SynonymsNAL; C112; NPL1; C1orf13;
Alternate namesN-acetylneuraminate lyase; N-acetylneuraminic acid aldolase; NALase; dihydrodipicolinate synthetase homolog 1; sialate-pyruvate lyase; sialic acid aldolase;
Chromosome1
Map Location1q25
EC Number4.1.3.3
SummaryThis gene encodes a member of the N-acetylneuraminate lyase sub-family of (beta/alpha)(8)-barrel enzymes. N-acetylneuraminate lyases regulate cellular concentrations of N-acetyl-neuraminic acid (sialic acid) by mediating the reversible conversion of sialic acid into N-acetylmannosamine and pyruvate. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
OrthologsView orthologs and multiple alignments for NPL

Proteins

N-acetylneuraminate lyase isoform 1
Refseq ID:NP_110396
Protein GI:13540533
UniProt ID:Q9BXD5
mRNA ID:NM_030769
Length:320
RefSeq Status:
MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHA
AEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGV
DEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDFSLALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDSAEAKL
KSLDFLSFTDLKDGNLEAGS
 
N-acetylneuraminate lyase isoform 2
Refseq ID:NP_001186979
Protein GI:318037618
UniProt ID:Q9BXD5
mRNA ID:NM_001200050
Length:301
RefSeq Status:
MSRAPGILASWRRAPSLSVQKGSQTARHTCHPEVPLGNCFLPVYKASPLTVTRLWAERLDQVIIHVGALSLKESQELAQHAAEIGADGIAVIAPFFLKPW
TKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGVDEQLLSALVMGATGAVGST
YNYLGKKTNQMLEAFEQKDFSLALNYQFCIQRFINFVVKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKASREFTDSAEAKLKSLDFLSFTDLKDGNLEAG
S
 
N-acetylneuraminate lyase isoform 3
Refseq ID:NP_001186985
Protein GI:318037609
UniProt ID:Q9BXD5
mRNA ID:NM_001200056
Length:284
RefSeq Status:
MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHA
AEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGV
DEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDFSLALNYQFCIQRFINFVVKLENSKLKVSKNQRTLPLGTTNFPFLH
 
N-acetylneuraminate lyase isoform 4
Refseq ID:NP_001186980
Protein GI:318037622
UniProt ID:Q9BXD5
mRNA ID:NM_001200051
Length:240
RefSeq Status:
MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHA
AEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGV
DEFCIQRFINFVVKLENSKLKVSKNQRTLPLGTTNFPFLH
 
N-acetylneuraminate lyase isoform 5
Refseq ID:NP_001186981
Protein GI:318037616
UniProt ID:
mRNA ID:NM_001200052
Length:230
RefSeq Status:
MAFPKKKLQGLVAATITPMTENGEINFSVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVTKGKDKLDQVIIHVGALSLKESQELAQHA
AEIGADGIAVIAPFFLKPWTKDILINFLKEVAAAAPALPFYYYHIPALTGVKIRAEELLDGILDKIPTFQGLKFSDTDLLDFGQCVDQNRQQQFAFLFGV
DEQLLSALVMGATGAVGSFVSRDLSTLLSN
 
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