MGP Database

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MGP006041

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate phosphatase 1
Protein EntrySGPP1_HUMAN
UniProt IDQ9BX95
SpeciesHuman
Comments
Comment typeDescription
FunctionHas enzymatic activity against both sphingosine 1- phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels. {ECO:0000269|PubMed:12815058}.
SimilarityBelongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12815058}; Multi-pass membrane protein {ECO:0000269|PubMed:12815058}.
Tissue SpecificityUbiquitous, with the strongest level in placenta and kidney. {ECO:0000269|PubMed:12815058}.
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