MGP Database

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MGP006042

UniProt Annotations

Entry Information
Gene Namesolute carrier family 38, member 1
Protein EntryS38A1_HUMAN
UniProt IDQ9H2H9
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=890 uM for 2-methylamino-isobutyric acid (MeAIB) (at pH 8.5) {ECO:0000269|PubMed:10891391};
Enzyme RegulationInhibited by potassium, choline ions and 2- methylamino-isobutyric acid (MeAIB) (By similarity). Inhibited by lithium and N-methyl-D-glucamine. {ECO:0000250, ECO:0000269|PubMed:10891391}.
FunctionFunctions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. {ECO:0000269|PubMed:10891391}.
InductionDown-regulated by bacterial lipopolysaccharides (LPS) in glial cells. Down-regulated upon hypoxia. {ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:16583402}.
Sequence CautionSequence=AAG44546.1; Type=Frameshift; Positions=443; Evidence={ECO:0000305}; Sequence=BAC11186.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the amino acid/polyamine transporter 2 family. {ECO:0000305}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000269|PubMed:15054072}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis. {ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:15054072, ECO:0000269|PubMed:16148032}.
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