MGP Database

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MGP006045

UniProt Annotations

Entry Information
Gene Namecollagen, type XXI, alpha 1
Protein EntryCOLA1_HUMAN
UniProt IDQ96P44
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q96P44-1; Sequence=Displayed; Name=2; IsoId=Q96P44-2; Sequence=VSP_031083, VSP_031085, VSP_031086; Note=No experimental confirmation available.; Name=3; IsoId=Q96P44-3; Sequence=VSP_031084; Note=No experimental confirmation available.;
Developmental StageHighest expression observed at the fetal stage. Expressed by smooth-muscle cells in the artery wall in a PDGF-dependent way. {ECO:0000269|PubMed:11863369}.
InductionStimulated by PDGF/platelet-derived growth factor. {ECO:0000269|PubMed:11863369}.
Sequence CautionSequence=AAH45597.1; Type=Frameshift; Positions=478; Evidence={ECO:0000305};
SimilarityBelongs to the fibril-associated collagens with interrupted helices (FACIT) family. {ECO:0000305}.
SimilarityContains 1 laminin G-like domain. {ECO:0000305}.
SimilarityContains 1 VWFA domain. {ECO:0000255|PROSITE- ProRule:PRU00219}.
SimilarityContains 7 collagen-like domains. {ECO:0000305}.
Subcellular LocationSecreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11863369}. Cytoplasm {ECO:0000269|PubMed:11863369}. Note=Found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle.
Tissue SpecificityHighly expressed in lymph node, jejunum, pancreas, stomach, trachea, testis, uterus and placenta; moderately expressed in brain, colon, lung, prostate, spinal cord, salivary gland and vascular smooth-muscle cells and very weakly expressed in heart, liver, kidney, bone marrow, spleen, thymus, skeletal muscle, adrenal gland and peripheral leukocytes. Expression in heart was higher in the right ventricle and atrium than in the left ventricle and atrium. {ECO:0000269|PubMed:11566190, ECO:0000269|PubMed:11863369}.
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