MGP Database

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MGP006073

UniProt Annotations

Entry Information
Gene NameRho GTPase activating protein 24
Protein Entry
UniProt ID
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q8N264-1; Sequence=Displayed; Name=2; IsoId=Q8N264-2; Sequence=VSP_023712, VSP_023715; Name=3; IsoId=Q8N264-3; Sequence=VSP_023711; Name=4; IsoId=Q8N264-4; Sequence=VSP_023717, VSP_023718; Note=No experimental confirmation available.; Name=5; IsoId=Q8N264-5; Sequence=VSP_023713, VSP_023714, VSP_023716; Note=No experimental confirmation available.;
DomainThe coiled coil domain mediates the interaction with FLNA leading to its recruitment to lamellae.
FunctionRho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
InductionIsoform 2 is up-regulated during capillary tube formation in umbilical vein endothelial cells. {ECO:0000269|PubMed:15302923}.
InteractionP21333:FLNA; NbExp=6; IntAct=EBI-988764, EBI-350432; P42858:HTT; NbExp=3; IntAct=EBI-988764, EBI-466029;
PtmPhosphorylated by ROCK, leading to activate the RacGAP activity. {ECO:0000269|PubMed:16862148}.
Sequence CautionSequence=AAO65178.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 1 Rho-GAP domain. {ECO:0000255|PROSITE- ProRule:PRU00172}.
Subcellular LocationCytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.
SubunitInteracts with FLNA. {ECO:0000269|PubMed:16862148}.
Tissue SpecificityIsoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells. {ECO:0000269|PubMed:15302923, ECO:0000269|PubMed:15611138, ECO:0000269|PubMed:16862148}.
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