MGP Database

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MGP006086

UniProt Annotations

Entry Information
Gene Namelon peptidase 2, peroxisomal
Protein EntryLONP2_HUMAN
UniProt IDQ86WA8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86WA8-1; Sequence=Displayed; Name=2; IsoId=Q86WA8-2; Sequence=VSP_056190; Note=No experimental confirmation available.;
FunctionATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:22002062}.
Sequence CautionSequence=BAB55278.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the peptidase S16 family. {ECO:0000255|HAMAP-Rule:MF_03121}.
SimilarityContains 1 Lon domain. {ECO:0000255|HAMAP- Rule:MF_03121}.
Subcellular LocationPeroxisome matrix {ECO:0000255|HAMAP- Rule:MF_03121, ECO:0000269|PubMed:14561759, ECO:0000269|PubMed:22002062}.
SubunitInteracts with PEX5. Interacts with TYSND1. {ECO:0000255|HAMAP-Rule:MF_03121, ECO:0000269|PubMed:22002062}.
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