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MGP Database

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MGP006105

UniProt Annotations

Entry Information

Gene Name	pyroglutamylated RFamide peptide receptor
Protein Entry	QRFPR_HUMAN
UniProt ID	Q96P65
Species	Human

Comments

Comment type	Description
Function	Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels. {ECO:0000269\|PubMed:12960173}.
Sequence Caution	Sequence=AAL26488.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity	Belongs to the G-protein coupled receptor 1 family. {ECO:0000255\|PROSITE-ProRule:PRU00521}.
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed widely in the brain with high levels in the hypothalamus, trigeminal ganglia and vestibular neurons, and moderate levels in the amygdala, cortex, pituitary, hippocampus, thalamus, caudate nucleus and medulla oblongata. In peripheral tissues, expressed at high levels in the retina and at moderate levels in the heart, kidney, testis and thyroid. {ECO:0000269\|PubMed:11574155, ECO:0000269\|PubMed:12714592}.