MGP Database

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MGP006147

UniProt Annotations

Entry Information
Gene Namecollagen, type XXV, alpha 1
Protein EntryCOPA1_HUMAN
UniProt IDQ9BXS0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1 {ECO:0000269|PubMed:11927537}; IsoId=Q9BXS0-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:11927537}; IsoId=Q9BXS0-2; Sequence=VSP_052200; Name=3 {ECO:0000269|PubMed:14656069}; IsoId=Q9BXS0-3; Sequence=VSP_052197, VSP_052198, VSP_052199;
CautionThe pyrrolidone carboxylic acid reported in PubMed:11927537 probably formed artifactually from Glu-113 during the extraction procedure in 70% formic acid. In PubMed:15522881, the protein was found to have unblocked Glu at the N-terminus. {ECO:0000305}.
FunctionInhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin. {ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705, ECO:0000269|PubMed:15853808, ECO:0000269|PubMed:16300410}.
PtmGlycosylated. {ECO:0000269|PubMed:15522881}.
PtmHydroxylated on 11% of proline residues and 49% of lysine residues. {ECO:0000269|PubMed:11927537, ECO:0000269|PubMed:15522881}.
PtmUndergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. {ECO:0000269|PubMed:11927537}.
SimilarityContains 7 collagen-like domains. {ECO:0000255}.
Subcellular LocationMembrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=After proteolytic cleavage, CLAC is secreted.
SubunitForms homodimers and homotrimers. Binds to the fibrillized forms of beta amyloid peptide 40 (beta-APP40) and beta amyloid peptide 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40. {ECO:0000269|PubMed:11927537, ECO:0000269|PubMed:15215182, ECO:0000269|PubMed:15522881, ECO:0000269|PubMed:15615705}.
Tissue SpecificityExpressed predominantly in brain. Deposited preferentially in primitive or neuritic amyloid plaques which are typical of Alzheimer disease. {ECO:0000269|PubMed:11927537}.
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