MGP Database

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MGP006217

UniProt Annotations

Entry Information
Gene NameATP-binding cassette, sub-family C (CFTR/MRP), member 10
Protein EntryMRP7_HUMAN
UniProt IDQ5T3U5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Mrp7; IsoId=Q5T3U5-1; Sequence=Displayed; Name=2; Synonyms=Mrp7A; IsoId=Q5T3U5-2; Sequence=VSP_021078, VSP_021079, VSP_021080;
Biophysicochemical PropertiesKinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) {ECO:0000269|PubMed:12527806}; Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius) {ECO:0000269|PubMed:12527806};
FunctionATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion. {ECO:0000269|PubMed:12527806, ECO:0000269|PubMed:15256465}.
Sequence CautionSequence=BAA92227.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15736.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
SimilarityBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
SimilarityContains 2 ABC transmembrane type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00441}.
SimilarityContains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular LocationCell membrane {ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:12566991, ECO:0000269|PubMed:15256465}.
Tissue SpecificityIsoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed. {ECO:0000269|PubMed:12566991}.
Web ResourceName=ABCMdb; Note=Database for mutations in ABC proteins; URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q5T3U5";
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