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MGP006219

Record overview

MGPD IDMGP006219
Gene ID89869
SpeciesHomo sapiens (Human)
Gene Namephospholipase C, zeta 1
Gene Symbol PLCZ1
SynonymsPLCzeta; NYD-SP27; PLC-zeta-1;
Alternate names1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; PI-phospholipase C zeta 1; PLC-zeta-1; PLCZ1; phosphoinositide phospholipase C-zeta-1; testis-development related NYD-SP27;
Chromosome12
Map Location12p12.3
EC Number3.1.4.11
SummaryThe protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
OrthologsView orthologs and multiple alignments for PLCZ1

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Refseq ID:NP_149114
Protein GI:25188201
UniProt ID:Q86YW0
mRNA ID:NM_033123
Length:608
RefSeq Status:
MEMRWFLSKIQDDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHREEIIEIFNTYSENRKILLASNLAQFLTQEQ
YAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKGCRCLE
IDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKK
IGTLKETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQHSRLYQQFNENNSIGETQARKLSKLRVHEFIFHTR
KFITRIYPKATRADSSNFNPQEFWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPITLTIRLISGIQLPLTHSS
SNKGDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASL
FVYVWYVR
 
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