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MGP006223

Record overview

MGPD IDMGP006223
Gene ID89910
SpeciesHomo sapiens (Human)
Gene Nameubiquitin protein ligase E3B
Gene Symbol UBE3B
SynonymsBPIDS;
Alternate namesubiquitin-protein ligase E3B;
Chromosome12
Map Location12q24.11
EC Number6.3.2.-;
SummaryThe modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
OrthologsView orthologs and multiple alignments for UBE3B

Proteins

ubiquitin-protein ligase E3B isoform 1
Refseq ID:NP_904324
Protein GI:35493952
UniProt ID:Q7Z3V4
mRNA ID:NM_183415
Length:1068
RefSeq Status:
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLC
RSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANIMGHL
NQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPVIAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCD
ILSKKLLESQEPAHAQPASPQNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQILTGLTYLDDLLPKLWAFIC
ELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLITILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQ
LSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFF
LSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVE
VSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
 
ubiquitin-protein ligase E3B isoform 1
Refseq ID:NP_569733
Protein GI:35493959
UniProt ID:Q7Z3V4
mRNA ID:NM_130466
Length:1068
RefSeq Status:
Protein sequence is identical to GI:35493952 (mRNA isoform)
 
ubiquitin-protein ligase E3B isoform 3
Refseq ID:NP_001257378
Protein GI:394025733
UniProt ID:Q7Z3V4
mRNA ID:NM_001270449
Length:244
RefSeq Status:
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDFFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLC
RSILSSMDAENEPKVWYVSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRGKGESLRPAMNHICANIMGHL
NQHGFYSVLQCCDGLFPDLVSYAPHNNPVRWSVGRSWYDWQLSR
 
ubiquitin-protein ligase E3B isoform 3
Refseq ID:NP_001257379
Protein GI:394025735
UniProt ID:Q7Z3V4
mRNA ID:NM_001270450
Length:244
RefSeq Status:
Protein sequence is identical to GI:394025733 (mRNA isoform)
 
ubiquitin-protein ligase E3B isoform 3
Refseq ID:NP_001257380
Protein GI:394025737
UniProt ID:Q7Z3V4
mRNA ID:NM_001270451
Length:244
RefSeq Status:
Protein sequence is identical to GI:394025733 (mRNA isoform)
 
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