MGP Database

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MGP006248

UniProt Annotations

Entry Information
Gene NameSEC11 homolog C (S. cerevisiae)
Protein EntrySC11C_HUMAN
UniProt IDQ9BY50
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityCleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.
FunctionComponent of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
SimilarityBelongs to the peptidase S26B family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000250}; Single- pass type II membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
SubunitComponent of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3. {ECO:0000250}.
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