MGP Database

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MGP006252

UniProt Annotations

Entry Information
Gene Nameceramide synthase 5
Protein EntryCERS5_HUMAN
UniProt IDQ8N5B7
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N5B7-1; Sequence=Displayed; Name=2; IsoId=Q8N5B7-2; Sequence=VSP_054572; Note=No experimental confirmation available.;
Catalytic ActivityAcyl-CoA + sphingosine = CoA + N- acylsphingosine.
FunctionDihydroceramide synthase. Catalyzes the acylation of sphingosine to form dihydroceramide, with high selectivity toward palmitoyl-CoA as acyl donor compared to stearoyl-CoA. Inhibited by fumonisin B1 (By similarity). {ECO:0000250}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityContains 1 homeobox DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00108}.
SimilarityContains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular LocationNucleus membrane {ECO:0000255|PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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