MGP Database

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MGP006265

UniProt Annotations

Entry Information
Gene Nameisopentenyl-diphosphate delta isomerase 2
Protein EntryIDI2_HUMAN
UniProt IDQ9BXS1
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityIsopentenyl diphosphate = dimethylallyl diphosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
FunctionCatalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000269|PubMed:17202134}.
PathwayIsoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
SimilarityBelongs to the IPP isomerase type 1 family. {ECO:0000305}.
SimilarityContains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule:PRU00794}.
Subcellular LocationPeroxisome {ECO:0000269|PubMed:17202134}.
Tissue SpecificityDetected in skeletal muscle. {ECO:0000269|PubMed:17202134}.
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