MGP Database

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MGP006268

UniProt Annotations

Entry Information
Gene NameCdk5 and Abl enzyme substrate 1
Protein EntryCABL1_HUMAN
UniProt IDQ8TDN4
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8TDN4-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q8TDN4-2; Sequence=VSP_012696, VSP_012697; Name=3; IsoId=Q8TDN4-3; Sequence=VSP_012695; Name=4; IsoId=Q8TDN4-4; Sequence=VSP_045014; Note=No experimental confirmation available.;
Developmental StageExpression in the endometrial epithelium fluctuates during the menstrual cycle, being greater during the secretory phase when compared with the proliferative phase. {ECO:0000269|PubMed:14729625}.
FunctionCyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
InductionUp-regulated by progesterone and down-regulated by estrogen in benign endometrium. {ECO:0000269|PubMed:14729625}.
InteractionQ00535:CDK5; NbExp=4; IntAct=EBI-604615, EBI-1041567; Q9H3D4-1:TP63; NbExp=7; IntAct=EBI-604615, EBI-2400586;
PtmPhosphorylated on Ser-313 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3 (By similarity). {ECO:0000250}.
SimilarityBelongs to the cyclin family. {ECO:0000305}.
Subcellular LocationNucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
SubunitFound in a complex with p53/TP53. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7 (By similarity). {ECO:0000250}.
Tissue SpecificityExpressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269|PubMed:11585773, ECO:0000269|PubMed:14729625}.
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