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MGP006299

UniProt Annotations

Entry Information
Gene Namenicotinate phosphoribosyltransferase
Protein EntryPNCB_HUMAN
UniProt IDQ6XQN6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6XQN6-1; Sequence=Displayed; Name=2; IsoId=Q6XQN6-2; Sequence=VSP_030612; Note=No experimental confirmation available.; Name=3; IsoId=Q6XQN6-3; Sequence=VSP_030610; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=44.3 uM for nicotinic acid (in the presence of 3mM ATP) {ECO:0000269|PubMed:21742010}; KM=22.1 uM for 5-phosphoribosyl-1-pyrophosphate (in the presence of 3mM ATP) {ECO:0000269|PubMed:21742010}; KM=27.3 uM for nicotinic acid (in the presence of inorganic phosphate) {ECO:0000269|PubMed:21742010}; KM=38.2 uM for 5-phosphoribosyl-1-pyrophosphate (in the presence of inorganic phosphate) {ECO:0000269|PubMed:21742010};
Catalytic ActivityNicotinate + 5-phospho-alpha-D-ribose 1- diphosphate + ATP + H(2)O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.
FunctionCatalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). Essential for NA to increase cellular NAD levels and prevent oxidative stress of the cells. {ECO:0000269|PubMed:17604275}.
FunctionCatalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP. {ECO:0000250}.
PathwayCofactor biosynthesis; NAD(+) biosynthesis; nicotinate D- ribonucleotide from nicotinate: step 1/1.
Sequence CautionSequence=AAH06284.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH32466.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the NAPRTase family. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000269|PubMed:17604275}.
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