MGP Database

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MGP006310

UniProt Annotations

Entry Information
Gene Namemucin 16, cell surface associated
Protein EntryMUC16_HUMAN
UniProt IDQ8WXI7
SpeciesHuman
Comments
Comment typeDescription
DomainComposed of three domains, a Ser-, Thr-rich N-terminal domain, a repeated domain containing more than 60 partially conserved tandem repeats of 156 amino acids each (AAs 12061-21862) and a C-terminal transmembrane contain domain with a short cytoplasmic tail.
FunctionThought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
InductionUp-regulated in ovarian cancer cells. {ECO:0000269|PubMed:12218296}.
MiscellaneousAntigen that is the basis for a widely used serum assay for the monitoring of patients with ovarian epithelial cancer. Due to lack of sensitivity for stage I disease and lack of specificity, it is of little value in the detection of early ovarian cancer. Due to its similarly elevated levels in some nonmalignant conditions, it is not specific enough to be used for population screening.
PolymorphismThe number of repeats is highly polymorphic.
PtmHeavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. {ECO:0000269|PubMed:12734200}.
PtmHeavily O-glycosylated; expresses both type 1 and type 2 core glycans. {ECO:0000269|PubMed:12734200}.
PtmMay be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. {ECO:0000269|PubMed:9276028}.
PtmMay contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
SimilarityContains 2 ANK repeats. {ECO:0000305}.
SimilarityContains 56 SEA domains. {ECO:0000255|PROSITE- ProRule:PRU00188}.
Subcellular LocationCell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
SubunitBinds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
Tissue SpecificityExpressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296, ECO:0000269|PubMed:16384952}.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MUC16ID41455ch19q13.html";
Web ResourceName=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/";
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