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MGP006312

UniProt Annotations

Entry Information
Gene Nameferritin mitochondrial
Protein EntryFTMT_HUMAN
UniProt IDQ8N4E7
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.
FunctionStores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. {ECO:0000269|PubMed:11323407, ECO:0000269|PubMed:15201052}.
SimilarityBelongs to the ferritin family. {ECO:0000305}.
SimilarityContains 1 ferritin-like diiron domain. {ECO:0000255|PROSITE-ProRule:PRU00085}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:11323407}.
SubunitHomooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.
Tissue SpecificityDetected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine. {ECO:0000269|PubMed:11323407}.
Web ResourceName=Wikipedia; Note=Ferritin entry; URL="http://en.wikipedia.org/wiki/Ferritin";
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