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MGP006349

UniProt Annotations

Entry Information
Gene Nameoxysterol binding protein-like 1A
Protein EntryOSBL1_HUMAN
UniProt IDQ9BXW6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=B; Synonyms=OSBPL1B, OSBP8L, ORP1L; IsoId=Q9BXW6-1; Sequence=Displayed; Name=A; Synonyms=OSBPL1A, OSBP8S; IsoId=Q9BXW6-2; Sequence=VSP_003779; Name=4; IsoId=Q9BXW6-4; Sequence=VSP_045443;
FunctionBinds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. {ECO:0000250, ECO:0000269|PubMed:16176980}.
Sequence CautionSequence=AAG53407.2; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305};
SimilarityBelongs to the OSBP family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 3 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}.
Subcellular LocationLate endosome {ECO:0000269|PubMed:16176980}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
SubunitInteracts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A. Interacts with OAS1B (By similarity). {ECO:0000250}.
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