MGP Database

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MGP006350

UniProt Annotations

Entry Information
Gene Nameprotein tyrosine phosphatase, mitochondrial 1
Protein EntryPTPM1_HUMAN
UniProt IDQ8WUK0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8WUK0-1; Sequence=Displayed; Name=2; IsoId=Q8WUK0-2; Sequence=VSP_015009; Name=3; IsoId=Q8WUK0-3; Sequence=VSP_045030, VSP_045031; Note=No experimental confirmation available.;
Catalytic Activity[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Catalytic ActivityPhosphatidylglycerophosphate + H(2)O = phosphatidylglycerol + phosphate.
Catalytic ActivityProtein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
CautionWas originally erroneously termed DUSP23. {ECO:0000305}.
FunctionLipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). {ECO:0000250}.
PathwayPhospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
Sequence CautionSequence=AAH14048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07545.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
SimilarityContains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.
Subcellular LocationMitochondrion inner membrane {ECO:0000250}. Note=Associated with the inner membrane. {ECO:0000250}.
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