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MGP006353

UniProt Annotations

Entry Information
Gene Namesolute carrier family 26 (anion exchanger), member 7
Protein EntryS26A7_HUMAN
UniProt IDQ8TE54
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1 {ECO:0000269|PubMed:11829495}; Synonyms=1A {ECO:0000269|PubMed:11829495}, 1B {ECO:0000269|PubMed:11829495}; IsoId=Q8TE54-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:11829495, ECO:0000269|PubMed:15489334}; Synonyms=B {ECO:0000269|PubMed:15489334}; IsoId=Q8TE54-2; Sequence=VSP_052689;
FunctionActs as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion. {ECO:0000250|UniProtKB:Q8R2Z3, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:12736153}.
MiscellaneousIs active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).
SimilarityBelongs to the SLC26A/SulP transporter (TC 2.A.53) family. {ECO:0000255}.
SimilarityContains 1 STAS domain. {ECO:0000255|PROSITE- ProRule:PRU00198}.
Subcellular LocationRecycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000269|PubMed:16524946}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269|PubMed:16524946}.
Tissue SpecificityExpressed in tonsillar high endothelial venule endothelial cells (HEVEC), placenta and in testis, expressed in a subgroup of basal cells in the epididymal ducts. {ECO:0000269|PubMed:11829495, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:15956810, ECO:0000269|PubMed:17504921}.
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