MGP Database

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MGP006356

UniProt Annotations

Entry Information
Gene Nameguanylate binding protein 4
Protein EntryGBP4_HUMAN
UniProt IDQ96PP9
SpeciesHuman
Comments
Comment typeDescription
FunctionBinds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity). {ECO:0000250}.
InductionBy interferon gamma during macrophage activation. {ECO:0000269|PubMed:17266443}.
Sequence CautionSequence=BAC85144.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily. {ECO:0000305}.
SimilarityContains 1 GB1/RHD3-type G (guanine nucleotide- binding) domain. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:17266443}. Nucleus {ECO:0000269|PubMed:17266443}.
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