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MGP006361

UniProt Annotations

Entry Information
Gene Namenitric oxide synthase trafficking
Protein EntryNOSTN_HUMAN
UniProt IDQ8IVI9
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; Synonyms=NOSTRINalpha; IsoId=Q8IVI9-1; Sequence=Displayed; Name=2; IsoId=Q8IVI9-2; Sequence=VSP_025885; Name=3; Synonyms=NOSTRINbeta; IsoId=Q8IVI9-3; Sequence=VSP_025884; Note=May negatively regulate transcription of the NOSTRIN gene. {ECO:0000269|PubMed:18980613}; Name=4; IsoId=Q8IVI9-4; Sequence=VSP_044995; Note=No experimental confirmation available. Ref.3 (BAG52717) sequence is in conflict in position: 238:T->I. {ECO:0000305};
DomainThe FCH domain is necessary for membrane targeting.
DomainThe SH3 domain mediates interaction with NOS3, DNM2 and WASL.
FunctionMultivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}.
InteractionQ05193:DNM1; NbExp=3; IntAct=EBI-1391643, EBI-713135; P11362:FGFR1; NbExp=5; IntAct=EBI-1391643, EBI-1028277; P29474:NOS3; NbExp=9; IntAct=EBI-1391643, EBI-1391623; O08816:Wasl (xeno); NbExp=3; IntAct=EBI-1391643, EBI-6142604;
SimilarityContains 1 FCH domain. {ECO:0000255|PROSITE- ProRule:PRU00083}.
SimilarityContains 1 SH3 domain. {ECO:0000255|PROSITE- ProRule:PRU00192}.
Subcellular LocationIsoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures.
Subcellular LocationIsoform 3: Nucleus {ECO:0000269|PubMed:18980613}.
SubunitHomotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1. {ECO:0000250, ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:16234328, ECO:0000269|PubMed:16807357}.
Tissue SpecificityExpressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level). {ECO:0000269|PubMed:12446846, ECO:0000269|PubMed:15847871}.
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