MGP Database

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MGP006367

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 1
Protein EntryACSM1_HUMAN
UniProt IDQ08AH1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08AH1-1; Sequence=Displayed; Name=2; IsoId=Q08AH1-2; Sequence=VSP_028391;
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic ActivityGTP + lipoate = diphosphate + lipoyl-GMP.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). Functions as GTP-dependent lipoate- activating enzyme that generates the substrate for lipoyltransferase (By similarity). {ECO:0000250}.
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.
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