MGP Database

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MGP006388

UniProt Annotations

Entry Information
Gene Namemucin-like 1
Protein EntryMUCL1_HUMAN
UniProt IDQ96DR8
SpeciesHuman
Comments
Comment typeDescription
FunctionMay play a role as marker for the diagnosis of metastatic breast cancer. {ECO:0000269|PubMed:12019145, ECO:0000269|PubMed:12595743, ECO:0000269|PubMed:15684711}.
PolymorphismThe number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors.
PtmO-glycosylated. {ECO:0000305|PubMed:12595743}.
Subcellular LocationSecreted {ECO:0000305|PubMed:15880534}. Membrane {ECO:0000305|PubMed:15880534}.
Tissue SpecificityExpressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells. {ECO:0000269|PubMed:12019145, ECO:0000269|PubMed:12595743, ECO:0000269|PubMed:15096563}.
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