MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP006392

UniProt Annotations

Entry Information
Gene Nameglutathione S-transferase omega 2
Protein EntryGSTO2_HUMAN
UniProt IDQ9H4Y5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9H4Y5-1; Sequence=Displayed; Name=2; IsoId=Q9H4Y5-2; Sequence=VSP_042567; Note=No experimental confirmation available.; Name=3; IsoId=Q9H4Y5-3; Sequence=VSP_045267; Note=No experimental confirmation available.;
Biophysicochemical PropertiespH dependence: Optimum pH is 7.5. {ECO:0000269|PubMed:15970797};
Catalytic Activity2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Catalytic ActivityMethylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H(2)O.
Catalytic ActivityRX + glutathione = HX + R-S-glutathione.
FunctionExhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). {ECO:0000269|PubMed:15970797}.
SimilarityBelongs to the GST superfamily. Omega family. {ECO:0000305}.
SimilarityContains 1 GST C-terminal domain. {ECO:0000305}.
SimilarityContains 1 GST N-terminal domain. {ECO:0000305}.
Tissue SpecificityExpressed in a range of tissues, including the liver, kidney, skeletal muscle and prostate. Strongest expression in the testis. {ECO:0000269|PubMed:12618591}.
  logo