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MGP006422

Record overview

MGPD IDMGP006422
Gene ID121278
SpeciesHomo sapiens (Human)
Gene Nametryptophan hydroxylase 2
Gene Symbol TPH2
SynonymsNTPH; ADHD7;
Alternate namestryptophan 5-hydroxylase 2; neuronal tryptophan hydroxylase; tryptophan 5-monooxygenase 2;
Chromosome12
Map Location12q21.1
EC Number1.14.16.4
SummaryThis gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for TPH2

Proteins

tryptophan 5-hydroxylase 2
Refseq ID:NP_775489
Protein GI:31795563
UniProt ID:Q8IWU9
mRNA ID:NM_173353
Length:490
RefSeq Status:
MQPAMMMFSSKYWARRGFSLDSAVPEEHQLLGSSTLNKPNSGKNDDKGNKGSSKREAATESGKTAVVFSLKNEVGGLVKALRLFQEKRVNMVHIESRKSR
RRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPENIWTEEEELEDVPWFPRKISELDKCSHRVLMYGSELDADHPGFKDNVYRQRRKYFVDVAMG
YKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNFPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQ
YIRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKAF
DPKTTCLQECLITTFQEAYFVSESFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
 
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