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MGP006432

UniProt Annotations

Entry Information
Gene Nameadenylosuccinate synthase like 1
Protein EntryPURA1_HUMAN
UniProt IDQ8N142
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N142-1; Sequence=Displayed; Name=2; IsoId=Q8N142-2; Sequence=VSP_008421; Note=No experimental confirmation available.;
Catalytic ActivityGTP + IMP + L-aspartate = GDP + phosphate + N(6)-(1,2-dicarboxyethyl)-AMP. {ECO:0000255|HAMAP-Rule:MF_03126}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000255|HAMAP-Rule:MF_03126}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP- Rule:MF_03126};
FunctionComponent of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). {ECO:0000250}.
PathwayPurine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03126}.
Sequence CautionSequence=AAH32039.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305}; Sequence=CAD62614.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the adenylosuccinate synthetase family. {ECO:0000255|HAMAP-Rule:MF_03126}.
Subcellular LocationCytoplasm {ECO:0000255|HAMAP-Rule:MF_03126, ECO:0000269|PubMed:15786719}.
SubunitHomodimer. {ECO:0000255|HAMAP-Rule:MF_03126}.
Tissue SpecificityPredominantly expressed in skeletal muscle and heart, as well as in several hematopoietic cell lines and solid tumors. {ECO:0000269|PubMed:15786719}.
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