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MGP006443

UniProt Annotations

Entry Information
Gene Nameacyl-CoA synthetase medium-chain family member 2A
Protein EntryACS2A_HUMAN
UniProt IDQ08AH3
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:19345228, ECO:0000269|Ref.5}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000269|PubMed:19345228, ECO:0000269|Ref.5};
FunctionHas medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). {ECO:0000250}.
Sequence CautionSequence=AAC23497.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitMonomer. {ECO:0000250}.
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