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MGP006452

UniProt Annotations

Entry Information
Gene Namearylformamidase
Protein EntryKFA_HUMAN
UniProt IDQ63HM1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q63HM1-1; Sequence=Displayed; Name=2; IsoId=Q63HM1-2; Sequence=VSP_038002; Note=No experimental confirmation available.;
Catalytic ActivityN-formyl-L-kynurenine + H(2)O = formate + L- kynurenine. {ECO:0000255|HAMAP-Rule:MF_03014}.
DomainThe main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. {ECO:0000255|HAMAP-Rule:MF_03014}.
FunctionCatalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. {ECO:0000255|HAMAP-Rule:MF_03014}.
PathwayAmino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2. {ECO:0000255|HAMAP-Rule:MF_03014}.
SimilarityBelongs to the kynurenine formamidase family. {ECO:0000255|HAMAP-Rule:MF_03014}.
Subcellular LocationCytoplasm, cytosol {ECO:0000255|HAMAP- Rule:MF_03014}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03014}. Note=Predominantly cytosolic. Some fraction is nuclear. {ECO:0000255|HAMAP-Rule:MF_03014}.
SubunitHomodimer. {ECO:0000255|HAMAP-Rule:MF_03014}.
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