MGP Database

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MGP006458

UniProt Annotations

Entry Information
Gene Namealkaline ceramidase 1
Protein EntryACER1_HUMAN
UniProt IDQ8TDN7
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityN-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Enzyme RegulationInhibited by sphingosine. {ECO:0000250}.
FunctionHydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity). {ECO:0000250}.
SimilarityBelongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityMainly expressed in epidermis. {ECO:0000269|PubMed:16477081}.
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