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MGP006483

UniProt Annotations

Entry Information
Gene Namefamily with sequence similarity 213, member B
Protein EntryPGFS_HUMAN
UniProt IDQ8TBF2
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=8; Name=1; IsoId=Q8TBF2-1; Sequence=Displayed; Name=2; IsoId=Q8TBF2-2; Sequence=VSP_024581; Note=No experimental confirmation available.; Name=3; IsoId=Q8TBF2-3; Sequence=VSP_040901; Note=No experimental confirmation available.; Name=4; IsoId=Q8TBF2-4; Sequence=VSP_040903; Note=No experimental confirmation available.; Name=5; IsoId=Q8TBF2-5; Sequence=VSP_040900, VSP_040902; Note=No experimental confirmation available.; Name=6; IsoId=Q8TBF2-6; Sequence=VSP_040900, VSP_040904; Note=No experimental confirmation available.; Name=7; IsoId=Q8TBF2-7; Sequence=VSP_040901, VSP_024581; Note=No experimental confirmation available.; Name=8; IsoId=Q8TBF2-8; Sequence=VSP_040900; Note=No experimental confirmation available.;
Catalytic ActivityThioredoxin + prostaglandin H(2) = thioredoxin disulfide + prostaglandin F(2-alpha).
FunctionCatalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By similarity). {ECO:0000250}.
SimilarityBelongs to the peroxiredoxin-like FAM213 family. Prostamide/prostaglandin F synthase subfamily. {ECO:0000305}.
Subcellular LocationCytoplasm, cytosol {ECO:0000250}.
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