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MGP006503

UniProt Annotations

Entry Information
Gene Namecytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Protein EntryCMPK2_HUMAN
UniProt IDQ5EBM0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5EBM0-1; Sequence=Displayed; Name=2; IsoId=Q5EBM0-2; Sequence=VSP_033238, VSP_033239; Note=No experimental confirmation available.; Name=3; IsoId=Q5EBM0-3; Sequence=VSP_033240; Note=No experimental confirmation available.; Name=4; IsoId=Q5EBM0-4; Sequence=VSP_033241; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3.09 mM for CMP; KM=6.3 mM for UMP; KM=1.31 mM for dCMP; KM=0.1 mM for dUMP; Vmax=1.64 umol/min/mg enzyme towards CMP; Vmax=0.19 umol/min/mg enzyme towards UMP; Vmax=1.77 umol/min/mg enzyme towards dCMP; Vmax=0.48 umol/min/mg enzyme towards dUMP;
Catalytic ActivityATP + (d)CMP = ADP + (d)CDP. {ECO:0000269|PubMed:23416111}.
Catalytic ActivityATP + nucleoside diphosphate = ADP + nucleoside triphosphate. {ECO:0000269|PubMed:23416111}.
FunctionMay participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:17999954, ECO:0000269|PubMed:23416111}.
SimilarityBelongs to the thymidylate kinase family. {ECO:0000305}.
Subcellular LocationMitochondrion {ECO:0000269|PubMed:17999954}.
Tissue SpecificityAmong all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269|PubMed:17999954}.
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