MGP Database

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MGP006504

UniProt Annotations

Entry Information
Gene Namemembrane bound O-acyltransferase domain containing 2
Protein EntryMBOA2_HUMAN
UniProt IDQ6ZWT7
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphoethanolamine = CoA + 1,2-diacyl-sn-glycero-3- phosphoethanolamine.
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Enzyme RegulationPartially inhibited by thimerosal.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18772128}.
PathwayLipid metabolism; phospholipid metabolism.
Sequence CautionSequence=BAC11204.1; Type=Erroneous initiation; Evidence={ECO:0000305};
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in neutrophils. {ECO:0000269|PubMed:18772128}.
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