MGP Database

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MGP006510

UniProt Annotations

Entry Information
Gene Namesphingosine-1-phosphate phosphatase 2
Protein EntrySGPP2_HUMAN
UniProt IDQ8IWX5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IWX5-1; Sequence=Displayed; Name=2; IsoId=Q8IWX5-2; Sequence=VSP_039385; Note=No experimental confirmation available.;
FunctionHas specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO:0000269|PubMed:12411432, ECO:0000269|PubMed:17113265}.
InductionStrongly induced by TNF, also induced by bacterial lipopolycaccharides (LPS) in neutrophils, endothelial cells, and other cell types. Not induced by growth-related factors. {ECO:0000269|PubMed:17113265}.
SimilarityBelongs to the type 2 lipid phosphate phosphatase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000269|PubMed:12411432}; Multi-pass membrane protein {ECO:0000269|PubMed:12411432}.
Tissue SpecificityExpressed strongly in kidney and heart, followed by brain, colon, small intestine and lung. Not detected in skeletal muscle, thymus, spleen, liver, placenta, and peripheral blood leukocytes. {ECO:0000269|PubMed:12411432}.
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