MGP Database

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MGP006511

UniProt Annotations

Entry Information
Gene Nameactivin A receptor, type IC
Protein EntryACV1C_HUMAN
UniProt IDQ8NER5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1 {ECO:0000269|PubMed:12606401}; IsoId=Q8NER5-1; Sequence=Displayed; Name=2 {ECO:0000269|PubMed:12606401}; Synonyms=B {ECO:0000303|PubMed:12606401}, soluble B {ECO:0000303|PubMed:12606401}; IsoId=Q8NER5-2; Sequence=VSP_051841; Name=3 {ECO:0000269|PubMed:12606401}; Synonyms=A {ECO:0000303|PubMed:12606401}, soluble A {ECO:0000303|PubMed:12606401}; IsoId=Q8NER5-3; Sequence=VSP_051842; Name=4 {ECO:0000269|PubMed:12606401}; Synonyms=Truncated {ECO:0000303|PubMed:12606401}; IsoId=Q8NER5-4; Sequence=VSP_051840;
Catalytic ActivityATP + [receptor-protein] = ADP + [receptor- protein] phosphate.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000305};
FunctionSerine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:15531507}.
SimilarityBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
SimilarityContains 1 GS domain. {ECO:0000255|PROSITE- ProRule:PRU00585}.
SimilarityContains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular LocationMembrane {ECO:0000269|PubMed:12606401}; Single-pass type I membrane protein {ECO:0000269|PubMed:12606401}.
SubunitBinds the type 2 receptor protein ACVR2A. {ECO:0000250}.
Tissue SpecificityPresent in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy. {ECO:0000269|PubMed:12063393, ECO:0000269|PubMed:12606401}.
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