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MGP006531

UniProt Annotations

Entry Information
Gene Nameacyl-CoA thioesterase 12
Protein EntryACO12_HUMAN
UniProt IDQ8WYK0
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WYK0-1; Sequence=Displayed; Name=2; IsoId=Q8WYK0-2; Sequence=VSP_055785, VSP_055786; Note=No experimental confirmation available.;
Catalytic ActivityAcetyl-CoA + H(2)O = CoA + acetate.
Enzyme RegulationInhibited by ADP. Active in the presence of ATP. {ECO:0000269|PubMed:16951743}.
FunctionHydrolyzes acetyl-CoA to acetate and CoA. {ECO:0000269|PubMed:16951743}.
PathwayCarbohydrate metabolism; pyruvate metabolism.
SimilarityContains 1 START domain. {ECO:0000255|PROSITE- ProRule:PRU00197}.
SimilarityContains 2 acyl coenzyme A hydrolase domains. {ECO:0000305}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16951743}.
SubunitHomodimer or homotetramer. {ECO:0000250}.
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