MGP Database

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MGP006558

UniProt Annotations

Entry Information
Gene Namediacylglycerol kinase, kappa
Protein EntryDGKK_HUMAN
UniProt IDQ5KSL6
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate. {ECO:0000269|PubMed:16210324}.
Enzyme RegulationInhibited in response to H(2)O(2). {ECO:0000269|PubMed:16210324}.
FunctionPhosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). {ECO:0000269|PubMed:16210324}.
PtmPhosphorylated at Tyr-78 by some member of the SRC family in response to H(2)O(2). {ECO:0000269|PubMed:16210324}.
SimilarityBelongs to the eukaryotic diacylglycerol kinase family. {ECO:0000305}.
SimilarityContains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
SimilarityContains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
SimilarityContains 2 phorbol-ester/DAG-type zinc fingers. {ECO:0000255|PROSITE-ProRule:PRU00226}.
Subcellular LocationCytoplasm {ECO:0000269|PubMed:16210324}. Membrane {ECO:0000269|PubMed:16210324}; Peripheral membrane protein {ECO:0000269|PubMed:16210324}.
SubunitDoes not form homooligomers.
Tissue SpecificityExpressed in testis, and to a lesser extent in placenta. {ECO:0000269|PubMed:16210324}.
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