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MGP006579

UniProt Annotations

Entry Information
Gene NameN-acetylneuraminic acid phosphatase
Protein EntryNANP_HUMAN
UniProt IDQ8TBE9
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=0.09 mM for N-acetylneuraminate 9-P {ECO:0000269|PubMed:16237198}; KM=19.2 mM for fructose 1,6-P2 {ECO:0000269|PubMed:16237198}; KM=2.7 mM for 6-P-gluconate {ECO:0000269|PubMed:16237198}; KM=5.9 mM for N-acetylglucosamine 6-P {ECO:0000269|PubMed:16237198}; Vmax=112 umol/min/mg enzyme with N-acetylneuraminate 9-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=6.10 umol/min/mg enzyme with fructose 1,6-P2 as substrate {ECO:0000269|PubMed:16237198}; Vmax=2.79 umol/min/mg enzyme with 6-P-gluconate as substrate {ECO:0000269|PubMed:16237198}; Vmax=2.46 umol/min/mg enzyme with N-acetylglucosamine 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.149 umol/min/mg enzyme with sorbitol 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.140 umol/min/mg enzyme with 3-P glycerate as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.095 umol/min/mg enzyme with P-serine as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.094 umol/min/mg enzyme with glycerol 3-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.090 umol/min/mg enzyme with ribulose 5-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.072 umol/min/mg enzyme with N-acetylmannosamine 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.063 umol/min/mg enzyme with arabinose 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.042 umol/min/mg enzyme with ribose 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.023 umol/min/mg enzyme with glucosamine 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with phosphoglycolate as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.019 umol/min/mg enzyme with fructose 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.017 umol/min/mg enzyme with glycerol 2-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.016 umol/min/mg enzyme with glucose 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.015 umol/min/mg enzyme with mannose 6-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.004 umol/min/mg enzyme with glucose 1-P as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.002 umol/min/mg enzyme with P-enolpyruvate as substrate {ECO:0000269|PubMed:16237198}; Vmax=0.001 umol/min/mg enzyme with ATP as substrate {ECO:0000269|PubMed:16237198};
Catalytic ActivityN-acylneuraminate 9-phosphate + H(2)O = N- acylneuraminate + phosphate. {ECO:0000269|PubMed:16237198}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:16237198};
Enzyme RegulationInhibited by vanadate and calcium. {ECO:0000269|PubMed:16237198}.
PathwayAmino-sugar metabolism; N-acetylneuraminate biosynthesis.
Sequence CautionSequence=BAB85055.1; Type=Miscellaneous discrepancy; Note=It seems to be derived from genomic DNA and not from cDNA.; Evidence={ECO:0000305};
SimilarityBelongs to the HAD-like hydrolase superfamily. NANP family. {ECO:0000305}.
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