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MGP006648

UniProt Annotations

Entry Information
Gene Namephospholipase B1
Protein EntryPLB1_HUMAN
UniProt IDQ6P1J6
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q6P1J6-1; Sequence=Displayed; Name=2; IsoId=Q6P1J6-2; Sequence=VSP_032226, VSP_032231, VSP_032232; Name=3; IsoId=Q6P1J6-3; Sequence=VSP_032227, VSP_032228; Name=4; IsoId=Q6P1J6-4; Sequence=VSP_032229, VSP_032230; Note=No experimental confirmation available.; Name=5; IsoId=Q6P1J6-5; Sequence=VSP_032225;
Catalytic Activity2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Catalytic ActivityPhosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
DomainRepeat 2 contains the catalytic domain. {ECO:0000250}.
Enzyme RegulationInhibited by diisopropyl fluorophosphate. {ECO:0000250}.
FunctionMembrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). {ECO:0000250}.
PtmUndergoes proteolytic cleavage in the ileum. {ECO:0000250}.
Sequence CautionSequence=BAB70920.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. {ECO:0000305}.
Subcellular LocationApical cell membrane {ECO:0000250}; Single- pass type I membrane protein {ECO:0000250}. Note=Present in the intestinal brush border membranes. {ECO:0000250}.
Tissue SpecificityExpressed in the epidermis (at protein level). {ECO:0000269|PubMed:12150957}.
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