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MGP006651

UniProt Annotations

Entry Information
Gene Nameuridine phosphorylase 2
Protein EntryUPP2_HUMAN
UniProt IDO95045
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=O95045-1; Sequence=Displayed; Name=2; IsoId=O95045-2; Sequence=VSP_043756; Note=No experimental confirmation available.;
Catalytic ActivityUridine + phosphate = uracil + alpha-D-ribose 1-phosphate.
Enzyme RegulationA conditional disulfide bridge can form within the protein that dislocates a critical phosphate-coordinating arginine Arg-100 away from the active site, disabling the enzyme. {ECO:0000269|PubMed:21855639}.
FunctionCatalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.
PathwayPyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.
Sequence CautionSequence=AAH33529.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
SimilarityBelongs to the PNP/UDP phosphorylase family. {ECO:0000305}.
Tissue SpecificityPredominantly expressed in kidney. {ECO:0000269|PubMed:12849978}.
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