MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
MGP006661

UniProt Annotations

Entry Information
Gene Namemembrane bound O-acyltransferase domain containing 1
Protein EntryMBOA1_HUMAN
UniProt IDQ6ZNC8
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6ZNC8-1; Sequence=Displayed; Name=2; IsoId=Q6ZNC8-2; Sequence=VSP_036729; Name=3; IsoId=Q6ZNC8-3; Sequence=VSP_036730, VSP_036731;
Catalytic ActivityAcyl-CoA + 1-acyl-sn-glycero-3- phosphatidylserine = CoA + 1,2-diacyl-sn-glycero-3- phosphatidylserine.
Enzyme RegulationPartially inhibited by thimerosal.
FunctionAcyltransferase which mediates the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L- serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3- phospho-L-serine or PS) (LPSAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. {ECO:0000269|PubMed:18772128}.
PathwayLipid metabolism; phospholipid metabolism.
SimilarityBelongs to the membrane-bound acyltransferase family. {ECO:0000305}.
Subcellular LocationMembrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue SpecificityExpressed in neutrophils. {ECO:0000269|PubMed:18772128}.
  logo