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MGP006668

UniProt Annotations

Entry Information
Gene Nameretinol dehydrogenase 10 (all-trans)
Protein EntryRDH10_HUMAN
UniProt IDQ8IZV5
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityAll-trans-retinol + NADP(+) = all-trans- retinal + NADPH. {ECO:0000269|PubMed:12407145}.
FunctionRetinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol. {ECO:0000269|PubMed:12407145}.
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular LocationMicrosome membrane {ECO:0000305}; Single- pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue SpecificityDetected in retina, kidney, liver, small intestine, placenta, lung, heart and skeletal muscle. {ECO:0000269|PubMed:12407145, ECO:0000269|PubMed:14596915}.
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