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MGP006676

UniProt Annotations

Entry Information
Gene Nameacyl-CoA wax alcohol acyltransferase 1
Protein EntryAWAT1_HUMAN
UniProt IDQ58HT5
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: Vmax=31.7 pmol/min/mg enzyme with [14C]oleoyl-CoA as substrate {ECO:0000269|PubMed:15671038}; Vmax=113 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate {ECO:0000269|PubMed:15671038};
Catalytic ActivityAcyl-CoA + a long-chain alcohol = CoA + a long-chain ester.
FunctionAcyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269|PubMed:15671038}.
SimilarityBelongs to the diacylglycerol acyltransferase family. {ECO:0000305}.
Subcellular LocationEndoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue SpecificityPredominantly expressed in skin, where it is limited to the sebaceous gland. Expressed in more mature, centrally located cells just before their rupture and sebum release. Also expressed in all tissues except spleen. Expressed at higher level in thymus, prostate and testis. {ECO:0000269|PubMed:15671038}.
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