MGP Database

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MGP006684

UniProt Annotations

Entry Information
Gene Namephosphatase, orphan 1
Protein EntryPHOP1_HUMAN
UniProt IDQ8TCT1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8TCT1-1; Sequence=Displayed; Name=2; Synonyms=PHOSPHO1-3a; IsoId=Q8TCT1-2; Sequence=VSP_040624; Name=3; IsoId=Q8TCT1-3; Sequence=VSP_045709; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=3 uM for PEA {ECO:0000269|PubMed:15175005}; KM=11.4 uM for PCho {ECO:0000269|PubMed:15175005}; pH dependence: Optimum pH is 6.7. {ECO:0000269|PubMed:15175005};
Catalytic ActivityO-phosphoethanolamine + H(2)O = ethanolamine + phosphate. {ECO:0000269|PubMed:15175005}.
Catalytic ActivityPhosphocholine + H(2)O = choline + phosphate. {ECO:0000269|PubMed:15175005}.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15175005};
FunctionPhosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
SimilarityBelongs to the HAD-like hydrolase superfamily. PHOSPHO family. {ECO:0000305}.
Tissue SpecificityExpressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. {ECO:0000269|PubMed:15050893}.
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