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MGP006706

Record overview

MGPD IDMGP006706
Gene ID166929
SpeciesHomo sapiens (Human)
Gene Namesphingomyelin synthase 2
Gene Symbol SGMS2
SynonymsSMS2;
Alternate namesphosphatidylcholine:ceramide cholinephosphotransferase 2; SM synthase;
Chromosome4
Map Location4q25
EC Number2.7.8.27
SummarySphingomyelin, a major component of cell and Golgi membranes, is made by the transfer of phosphocholine from phosphatidylcholine onto ceramide, with diacylglycerol as a side product. The protein encoded by this gene is an enzyme that catalyzes this reaction primarily at the cell membrane. The synthesis is reversible, and this enzyme can catalyze the reaction in either direction. The encoded protein is required for cell growth. Three transcript variants encoding the same protein have been found for this gene. There is evidence for more variants, but the full-length nature of their transcripts has not been determined.[provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for SGMS2

Proteins

phosphatidylcholine:ceramide cholinephosphotransferase 2
Refseq ID:NP_001129729
Protein GI:210147407
UniProt ID:Q8NHU3
mRNA ID:NM_001136257
Length:365
RefSeq Status:
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVV
HERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKV
QRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNL
KVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
 
phosphatidylcholine:ceramide cholinephosphotransferase 2
Refseq ID:NP_001129730
Protein GI:210147409
UniProt ID:Q8NHU3
mRNA ID:NM_001136258
Length:365
RefSeq Status:
Protein sequence is identical to GI:210147407 (mRNA isoform)
 
phosphatidylcholine:ceramide cholinephosphotransferase 2
Refseq ID:NP_689834
Protein GI:22749271
UniProt ID:Q8NHU3
mRNA ID:NM_152621
Length:365
RefSeq Status:
Protein sequence is identical to GI:210147407 (mRNA isoform)
 
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