Log in / Register

MGP Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

MGP006714

UniProt Annotations

Entry Information

Gene Name	indoleamine 2,3-dioxygenase 2
Protein Entry	I23O2_HUMAN
UniProt ID	Q6ZQW0
Species	Human

Comments

Comment type	Description
Alternative Products	Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZQW0-1; Sequence=Displayed; Name=2; IsoId=Q6ZQW0-2; Sequence=VSP_024857, VSP_024858, VSP_024859;
Catalytic Activity	L-tryptophan + O(2) = N-formyl-L-kynurenine. {ECO:0000269\|PubMed:17671174}.
Cofactor	Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250}; Note=Binds 1 heme group per subunit. {ECO:0000250};
Enzyme Regulation	Activity is inhibited by D-1MT (1-methyl-D- tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan). {ECO:0000269\|PubMed:17671174}.
Function	Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. {ECO:0000269\|PubMed:17671174}.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
Similarity	Belongs to the indoleamine 2,3-dioxygenase family. {ECO:0000305}.
Tissue Specificity	Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. {ECO:0000269\|PubMed:17671174}.
Web Resource	Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/IDO2ID44387ch8p11.html";